Date of Award

Spring 2022

Document Type



College of Natural and Health Sciences

Primary Advisor

Professor Wendy Barry


Glioblastoma is reported to be the most aggressive and common brain tumor in adults (Davis, 2016). To help alleviate pain in patients with glioblastoma, floatation-REST (Restricted Environmental Stimulation Technique) is proposed. Such therapy has been shown to benefit chronic tension headaches, muscle tension, and other stress-related pain conditions (Feinstein, 2018). The magnesium and sulfate components of Epsom salt combined with controlled warm water allow the muscles and joints to relax. Studies show that magnesium targets the Adrenocorticotropic Hormone (ACTH) produced by the Anterior Pituitary Gland which in turn affects cortisol hormone levels to activate the body's immune defenses and eliminate the cause of pain and possible tissue recovery. This study aims to develop a conceptual framework that can be used to determine the possible effect of floatation-REST on cortisol levels of patients with glioblastoma for pain management. KEY WORDS: glioblastoma, cortisol, cancer, hormone, sensory deprivation tank, floatation-REST, pain