Date of Award

Spring 2022

Document Type

Thesis

College

College of Natural and Health Sciences

Primary Advisor

Dr. Aimee Franklin

Abstract

Alzheimer’s disease (AD) is one of the most common types of neurodegenerative disease. There are currently no treatment methods for AD, but there are treatments for some of the symptoms. Aberrant levels of both O-GlcNAcylation and GSK3ß have been found in patients with AD. Studies have suggested that there is a relationship between the level of O-GlcNAcylation and the phosphorylation of GSK3ß. In order to discover new treatment methods, the phosphorylation of GSK3ß should be explored. This study uses a western blot analysis to quantify the ratio of p-GSK3ß:GSK3ß between the experimental group (higher levels of O-GlcNAcylation) and a control group. The preliminary results suggested that there was no significant difference in the phosphorylation of GSK3ß when the levels of O-GlcNAcylation are increased.

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